1911 Encyclopædia Britannica/Spleen
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SPLEEN (Gr. σπλήν), a vascular organ situated on the left side of the abdomen (see Ductless Glands). It was supposed in olden times to be the seat of ill-humour and melancholy, whence such phrases as "to have the spleen," to be out of temper, sulky, morose, "splenetic."