An Etymological Dictionary of the German Language/Griesgram
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Griesgram, m., ‘ill-humour, spleen,’ from MidHG. grisgram, m., ‘gnashing of teeth’; allied to MidHG. grisgramen, -grammen, ‘to gnash with the teeth, snarl,’ OHG. grisgramôn, gristgrimmôn, ‘to gnash,’ AS. gristbîtung, ‘gnashing of teeth.’ The first syllable represents grist-, but that does not make the early history of the word clearer.