An Etymological Dictionary of the German Language/Weisel
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Weisel, m., ‘queen bee,’ from the equiv. MidHG. wîsel, m., lit. ‘leader, guide.’ Allied to weisen, vb., ‘to show, direct, point,’ from MidHG. wîsen wk. (str.) vb., OHG. wîsen (from *wîsjan), wk. vb., ‘to show, direct, instruct’; a derivative of weise (hence lit. ‘to make wise’).