ICD-10-CM (2010)/CHAPTER 3

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Excludes2: autoimmune disease (systemic) NOS (M35.9)

certain conditions originating in the perinatal period (P00-P96)

complications of pregnancy, childbirth and the puerperium (O00-O99)

congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)

endocrine, nutritional and metabolic diseases (E00-E90)

human immunodeficiency virus [HIV] disease (B20)

injury, poisoning and certain other consequences of external causes (S00-T98)

neoplasms (C00-D49)

symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

This chapter contains the following blocks:

D50-D53 Nutritional anemias

D55-D59 Hemolytic anemias

D60-D64 Aplastic and other anemias and other bone marrow failure syndromes

D65-D69 Coagulation defects, purpura and other hemorrhagic conditions

D70-D77 Other disorders of blood and blood-forming organs

D78 Intraoperative and postprocedural complications of spleen

D80-D89 Certain disorders involving the immune mechanism

Nutritional anemias (D50-D53)

D50 Iron deficiency anemia

Includes: asiderotic anemia

hypochromic anemia

D50.0 Iron deficiency anemia secondary to blood loss (chronic)

Posthemorrhagic anemia (chronic)

Excludes1: acute posthemorrhagic anemia (D62)

congenital anemia from fetal blood loss (P61.3)

D50.1 Sideropenic dysphagia

Kelly-Paterson syndrome

Plummer-Vinson syndrome

D50.8 Other iron deficiency anemias

Iron deficiency anemia due to inadequate dietary iron intake

D50.9 Iron deficiency anemia, unspecified

D51 Vitamin B12 deficiency anemia

Excludes1: vitamin B12 deficiency (E53.8)

D51.0 Vitamin B12 deficiency anemia due to intrinsic factor deficiency

Addison anemia

Biermer anemia

Pernicious (congenital) anemia

Congenital intrinsic factor deficiency

D51.1 Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria

Imerslund (-Gr?sbeck) syndrome

Megaloblastic hereditary anemia

D51.2 Transcobalamin II deficiency

D51.3 Other dietary vitamin B12 deficiency anemia

Vegan anemia

D51.8 Other vitamin B12 deficiency anemias

D51.9 Vitamin B12 deficiency anemia, unspecified

D52 Folate deficiency anemia

Excludes1: folate deficiency without anemia (E53.8)

D52.0 Dietary folate deficiency anemia

Nutritional megaloblastic anemia

D52.1 Drug-induced folate deficiency anemia

Code first (T36-T50) to identify drug

D52.8 Other folate deficiency anemias

D52.9 Folate deficiency anemia, unspecified

Folic acid deficiency anemia NOS

D53 Other nutritional anemias

Includes: megaloblastic anemia unresponsive to vitamin B12 or folate therapy

D53.0 Protein deficiency anemia

Amino-acid deficiency anemia

Orotaciduric anemia

Excludes1: Lesch-Nyhan syndrome (E79.1)

D53.1 Other megaloblastic anemias, not elsewhere classified

Megaloblastic anemia NOS

Excludes1: Di Guglielmo's disease (C94.0)

D53.2 Scorbutic anemia

Excludes1: scurvy (E54)

D53. 8 Other specified nutritional anemias

Anemia associated with deficiency of copper

Anemia associated with deficiency of molybdenum

Anemia associated with deficiency of zinc

Excludes1: nutritional deficiencies without anemia, such as:

copper deficiency NOS (E61.0)

molybdenum deficiency NOS (E61.5)

zinc deficiency NOS (E60)

D53.9 Nutritional anemia, unspecified

Simple chronic anemia

Excludes1: anemia NOS (D64.9)

Hemolytic anemias (D55-D59)

D55 Anemia due to enzyme disorders

Excludes1: drug-induced enzyme deficiency anemia (D59.2)

D55.0 Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency

Favism

G6PD deficiency anemia

D55.1 Anemia due to other disorders of glutathione metabolism

Anemia (due to) enzyme deficiencies, except G6PD, related to the hexose monophosphate [HMP] shunt pathway

Anemia (due to) hemolytic nonspherocytic (hereditary), type I

D55.2 Anemia due to disorders of glycolytic enzymes

Hemolytic nonspherocytic (hereditary) anemia, type II

Hexokinase deficiency anemia

Pyruvate kinase [PK] deficiency anemia

Triose-phosphate isomerase deficiency anemia

Excludes1: disorders of glycolysis not associated with anemia (E74.8)

D55.3 Anemia due to disorders of nucleotide metabolism

D55.8 Other anemias due to enzyme disorders

D55.9 Anemia due to enzyme disorder, unspecified

D56 Thalassemia

Excludes1: sickle-cell thalassemia (D57.4-)

D56.0 Alpha thalassemia

Alpha thalassemia major

Hemoglobin H disease

Severe alpha thalassemia

Triple gene defect alpha thalassemia

Excludes1: alpha thalassemia minor (D56.3)

asymptomatic alpha thalassemia (D56.3)

hydrops fetalis due to hemolytic disease (P56.-)

D56.1 Beta thalassemia

Beta thalassemia major

Cooley' s anemia

Homozygous beta thalassemia

Severe beta thalassemia

Thalassemia intermedia

Excludes1: beta thalassemia minor (D56.3)

delta-beta thalassemia (D56.2)

sickle-cell beta thalassemia (D57.4-)

D56.2 Delta-beta thalassemia

Homozygous delta-beta thalassemia

Excludes1: delta-beta thalassemia minor (D56.3)

D56.3 Thalassemia minor

Alpha thalassemia minor

Alpha thalassemia trait

Beta thalassemia minor

Delta-beta thalassemia minor

Excludes1: alpha thalassemia (D56.0)

beta thalassemia (D56.1)

delta-beta thalassemia (D56.2)

D56.4 Hereditary persistence of fetal hemoglobin [HPFH]

D56.8 Other thalassemias

Hb-Bart's disease

Excludes1: sickle cell anemia (D57.-)

sickle-cell thalassemia (D57.4)

D56.9 Thalassemia, unspecified

Mediterranean anemia (with other hemoglobinopathy)

Thalassemia (minor) (mixed) (with other hemoglobinopathy)

D57 Sickle-cell disorders

Use additional code for any associated fever (R50.81)

Excludes1: other hemoglobinopathies (D58.-)

D57.0 Hb-SS disease with crisis

Sickle-cell disease NOS with crisis

Hb-SS disease with vasoocclusive pain

D57.00 Hb-SS disease with crisis, unspecified

D57.01 Hb-SS disease with acute chest syndrome

D57.02 Hb-SS disease with splenic sequestration

D57.1 Sickle-cell disease without crisis

Hb-SS disease without crisis

Sickle-cell anemia NOS

Sickle-cell disease NOS

Sickle-cell disorder NOS

D57.2 Sickle-cell/Hb-C disease

Hb-SC disease

Hb-S/Hb-C disease

D57.20 Sickle-cell/Hb-C disease without crisis

D57.21 Sickle-cell/Hb-C disease with crisis

D57. 211 Sickle-cell/Hb-C disease with acute chest syndrome

D57.212 Sickle-cell/Hb-C disease with splenic sequestration

D57.219 Sickle-cell/Hb-C disease with crisis, unspecified

Sickle-cell/Hb-C disease with crisis NOS

D57.3 Sickle-cell trait

Hb-S trait

Heterozygous hemoglobin S

D57.4 Sickle-cell thalassemia

Sickle-cell beta thalassemia

Thalassemia Hb-S disease

D57.40 Sickle-cell thalassemia without crisis

Sickle-cell thalassemia NOS

D57.41 Sickle-cell thalassemia with crisis

Sickle-cell thalassemia with vasoocclusive pain

D57.411 Sickle-cell thalassemia with acute chest syndrome

D57.412 Sickle-cell thalassemia with splenic sequestration

D57.419 Sickle-cell thalassemia with crisis, unspecified

Sickle-cell thalassemia with crisis NOS

D57.8 Other sickle-cell disorders

Hb-SD disease

Hb-SE disease

D57.80 Other sickle-cell disorders without crisis

D57.81 Other sickle-cell disorders with crisis

D57.811 Other sickle-cell disorders with acute chest syndrome

D57.812 Other sickle-cell disorders with splenic sequestration

D57.819 Other sickle-cell disorders with crisis, unspecified

Other sickle-cell disorders with crisis NOS

D58 Other hereditary hemolytic anemias

Excludes1: hemolytic anemia of the newborn (P55.-)

D58.0 Hereditary spherocytosis

Acholuric (familial) jaundice

Congenital (spherocytic) hemolytic icterus

Minkowski-Chauffard syndrome

D58.1 Hereditary elliptocytosis

Elliptocytosis (congenital)

Ovalocytosis (congenital) (hereditary)

D58.2 Other hemoglobinopathies

Abnormal hemoglobin NOS

Congenital Heinz body anemia

Hb-C disease

HbD disease

Hb-E disease

Hemoglobinopathy NOS

Unstable hemoglobin hemolytic disease

Excludes1: familial polycythemia (D75.0)

Hb-M disease (D74.0)

hereditary persistence of fetal hemoglobin [HPFH] (D56.4)

high-altitude polycythemia (D75.1)

methemoglobinemia (D74.-)

D58.8 Other specified hereditary hemolytic anemias

D58.9 Hereditary hemolytic anemia, unspecified

D59 Acquired hemolytic anemia

D59.0 Drug-induced autoimmune hemolytic anemia

Code first (T36-T50) to identify drug

D59.1 Other autoimmune hemolytic anemias

Autoimmune hemolytic disease (cold type) (warm type)

Chronic cold hemagglutinin disease

Cold agglutinin disease

Cold agglutinin hemoglobinuria

Cold type (secondary) (symptomatic) hemolytic anemia

Warm type (secondary) (symptomatic) hemolytic anemia

Excludes1: Evans syndrome (D69.41)

hemolytic disease of newborn (P55.-)

paroxysmal cold hemoglobinuria (D59.6)

D59.2 Drug-induced nonautoimmune hemolytic anemia

Drug-induced enzyme deficiency anemia

Code first (T36-T50) to identify drug

D59.3 Hemolytic-uremic syndrome

D59.4 Other nonautoimmune hemolytic anemias

Mechanical hemolytic anemia

Microangiopathic hemolytic anemia

Toxic hemolytic anemia

D59.5 Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]

Excludes1: hemoglobinuria NOS (R82.3)

D59.6 Hemoglobinuria due to hemolysis from other external causes

Hemoglobinuria from exertion

March hemoglobinuria

Paroxysmal cold hemoglobinuria

Use additional code (Chapter 20) to identify external cause

Excludes1: hemoglobinuria NOS (R82.3)

D59.8 Other acquired hemolytic anemias

D59.9 Acquired hemolytic anemia, unspecified

Idiopathic hemolytic anemia, chronic

Aplastic and other anemias and other bone marrow failure syndromes (D60-D64)

D60 Acquired pure red cell aplasia [erythroblastopenia]

Includes: red cell aplasia (acquired) (adult) (with thymoma)

Excludes1: congenital red cell aplasia (D61.01)

D60.0 Chronic acquired pure red cell aplasia

D60.1 Transient acquired pure red cell aplasia

D60.8 Other acquired pure red cell aplasias

D60.9 Acquired pure red cell aplasia, unspecified

D61 Other aplastic anemias and other bone marrow failure syndromes

Excludes1: neutropenia (D70.-)

D61.0 Constitutional aplastic anemia

D61.01 Constitutional (pure) red blood cell aplasia

Excludes1: acquired red cell aplasia (D60.9)

Blackfan-Diamond syndrome

Congenital (pure) red cell aplasia

Familial hypoplastic anemia

Primary (pure) red cell aplasia

Red cell (pure) aplasia of infants

D61.09 Other constitutional aplastic anemia

Fanconi's anemia

Pancytopenia with malformations

D61.1 Drug-induced aplastic anemia

Code first (T36-T50) to identify drug

D61.2 Aplastic anemia due to other external agents

Code first (T51-T65) to identify cause

D61.3 Idiopathic aplastic anemia

D61.8 Other specified aplastic anemias and other bone marrow failure syndromes

D61.81 Pancytopenia

Excludes1: pancytopenia (due to) (with):

aplastic anemia (D61.-)

bone marrow infiltration (D61.82)

congenital (pure) red cell aplasia (D61.01)

drug induced (D61.1)

hairy cell leukemia (C91.4-)

human immunodeficiency virus disease (B20.-)

leukoerythroblastic anemia (M61.82)

myelodysplastic syndromes (D46.-)

myeloproliferative disease (D47.1)

D61.82 Myelophthisis

Leukoerythroblastic anemia

Myelophthisic anemia

Panmyelophthisis

Code also the underlying disorder, such as:

malignant neoplasm of breast (C50.-)

tuberculosis (A15.-)

Excludes1: idiopathic myelofibrosis (D47.1)

myelofibrosis NOS (D75.81)

myelofibrosis with myeloid metaplasia (D47.4)

primary myelofibrosis (D47.1)

secondary myelofibrosis (D75.81)

D61.89 Other specified aplastic anemias and other bone marrow failure syndromes

D61.9 Aplastic anemia, unspecified

Hypoplastic anemia NOS

Medullary hypoplasia

D62 Acute posthemorrhagic anemia

Excludes1: anemia due to chronic blood loss (D50.0)

blood loss anemia NOS (D50.0)

congenital anemia from fetal blood loss (P61.3)

D63 Anemia in chronic diseases classified elsewhere

D63.0 Anemia in neoplastic disease

Code first neoplasm (C00-D49)

Excludes1: anemia due to antineoplastic chemotherapy (D64.81)

D63.1 Anemia in chronic kidney disease

Erythropoietin resistant anemia (EPO resistant anemia)

Code first underlying chronic kidney disease (CKD) (N18.-)

D63.8 Anemia in other chronic diseases classified elsewhere

Code first underlying disease, such as:

diphyllobothriasis (B70.0)

hookworm disease (B76.0-B76.9)

hypothyroidism (E00.0-E03.9)

malaria (B50.0-B54)

symptomatic late syphilis (A52.79)

tuberculosis (A18.89)

D64 Other anemias

Excludes1: refractory anemia (D46.-)

D64.0 Hereditary sideroblastic anemia

Sex-linked hypochromic sideroblastic anemia

D64.1 Secondary sideroblastic anemia due to disease

Code first underlying disease

D64.2 Secondary sideroblastic anemia due to drugs and toxins

Code first (T36-T65) to identify drug or toxin

D64. 3 Other sideroblastic anemias

Sideroblastic anemia NOS

Pyridoxine-responsive sideroblastic anemia NEC

D64.4 Congenital dyserythropoietic anemia

Dyshematopoietic anemia (congenital)

Excludes1: Blackfan-Diamond syndrome (D61.01)

Di Guglielmo's disease (C94.0)

D64.8 Other specified anemias

D64.81 Anemia due to antineoplastic chemotherapy

Antineoplastic chemotherapy induced anemia

Excludes1: anemia in neoplastic disease (D63.0)

aplastic anemia due to antineoplastic chemotherapy (D61.1)

D64.89 Other specified anemias

Infantile pseudoleukemia

D64.9 Anemia, unspecified

Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)

D65 Disseminated intravascular coagulation [defibrination syndrome]

Includes: afibrinogenemia, acquired

consumption coagulopathy

diffuse or disseminated intravascular coagulation [DIC]

fibrinolytic hemorrhage, acquired

fibrinolytic purpura

purpura fulminans

Excludes1: disseminated intravascular coagulation (complicating):

abortion or ectopic or molar pregnancy (O00-O07, O08.1)

in newborn (P60)

pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

D66 Hereditary factor VIII deficiency

Includes: classical hemophilia

deficiency factor VIII (with functional defect)

hemophilia NOS

hemophilia A

Excludes1: factor VIII deficiency with vascular defect (D68.0)

D67 Hereditary factor IX deficiency

Includes: christmas disease

factor IX deficiency (with functional defect)

hemophilia B

plasma thromboplastin component [PTC] deficiency

D68 Other coagulation defects

Excludes1: abnormal coagulation profile (R79.1)

coagulation defects complicating:

abortion or ectopic or molar pregnancy (O00-O07, O08.1)

pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

D68.0 Von Willebrand's disease

Angiohemophilia

Factor VIII deficiency with vascular defect

Vascular hemophilia

Excludes1: capillary fragility (hereditary) (D69.8)

factor VIII deficiency NOS (D66)

factor VIII deficiency with functional defect (D66)

D68.1 Hereditary factor XI deficiency

Hemophilia C

Plasma thromboplastin antecedent [PTA] deficiency

Rosenthal?s disease

D68.2 Hereditary deficiency of other clotting factors

AC globulin deficiency

Congenital afibrinogenemia

Deficiency of factor I [fibrinogen]

Deficiency of factor II [prothrombin]

Deficiency of factor V [labile]

Deficiency of factor VII [stable]

Deficiency of factor X [Stuart-Prower]

Deficiency of factor XII [Hageman]

Deficiency of factor XIII [fibrin stabilizing]

Dysfibrinogenemia (congenital)

Hypoproconvertinemia

Owren's disease

Proaccelerin deficiency

D68.3 Hemorrhagic disorder due to circulating anticoagulants

D68.31 Hemorrhagic disorder due to intrinsic circulating anticoagulants

Hemorrhagic disorder due to intrinsic increase in antithrombin

Hemorrhagic disorder due to intrinsic increase in anti-VIIIa

Hemorrhagic disorder due to intrinsic increase in anti-IXa

Hemorrhagic disorder due to intrinsic increase in anti-Xa

Hemorrhagic disorder due to intrinsic increase in anti-XIa

Hyperheparinemia

D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants

Drug-induced hemorrhagic disorder

Code first (T45.5-) to identify any administered anticoagulant

D68.4 Acquired coagulation factor deficiency

Deficiency of coagulation factor due to liver disease

Deficiency of coagulation factor due to vitamin K deficiency

Excludes1: vitamin K deficiency of newborn (P53)

D68.5 Primary thrombophilia

Primary hypercoagulable states

Excludes1: lupus anticoagulant (D68.62)

thrombotic thrombocytopenic purpura (M31.1)

D68.51 Activated protein C resistance

Factor V Leiden mutation

D68.52 Prothrombin gene mutation

D68.59 Other primary thrombophilia

Antithrombin III deficiency

Hypercoagulable state NOS

Primary hypercoagulable state NEC

Primary thrombophilia NEC

Protein C deficiency

Protein S deficiency

Thrombophilia NOS

D68.6 Other thrombophilia

Other hypercoagulable states

Excludes1: diffuse or disseminated intravascular coagulation [DIC] (D65)

heparin induced thrombocytopenia (HIT) (D75.82)

hyperhomocysteinemia (E72.11)

D68.61 Anticardiolipin syndrome

Antiphospholipid syndrome

Excludes1: lupus anticoagulant syndrome (D68.62)

D68.62 Lupus anticoagulant syndrome

Lupus anticoagulant

Presence of systemic lupus erythematosus [SLE] inhibitor

Excludes1: anticardiolipin syndrome (D68.61)

antiphospholipid syndrome (D68.61)

D68.69 Other thrombophilia

Hypercoagulable states NEC

Secondary hypercoagulable state NOS

D68.8 Other specified coagulation defects

Excludes1: hemorrhagic disease of newborn (P53)

D68.9 Coagulation defect, unspecified

D69 Purpura and other hemorrhagic conditions

Excludes1: benign hypergammaglobulinemic purpura (D89.0)

cryoglobulinemic purpura (D89.1)

essential (hemorrhagic) thrombocythemia (D47.3)

hemorrhagic thrombocythemia (D47.3)

purpura fulminans (D65)

thrombotic thrombocytopenic purpura (M31.1)

Waldenström's hypergammaglobulinemic purpura (D89.0)

D69. 0 Allergic purpura

Allergic vasculitis

Nonthrombocytopenic hemorrhagic purpura

Nonthrombocytopenic idiopathic purpura

Purpura anaphylactoid

Purpura Henoch(-Sch?nlein)

Purpura rheumatica

Vascular purpura

Excludes1: thrombocytopenic hemorrhagic purpura (D69.3)

D69.1 Qualitative platelet defects

Bernard-Soulier [giant platelet] syndrome

Glanzmann's disease

Grey platelet syndrome

Thromboasthenia (hemorrhagic) (hereditary)

Thrombocytopathy

Excludes1: von Willebrand's disease (D68.0)

D69.2 Other nonthrombocytopenic purpura

Purpura NOS

Purpura simplex

Senile purpura

D69.3 Immune thrombocytopenic purpura

Hemorrhagic (thrombocytopenic) purpura

Idiopathic thrombocytopenic purpura

Tidal platelet dysgenesis

D69.4 Other primary thrombocytopenia

Excludes1: transient neonatal thrombocytopenia (P61.0)

Wiskott-Aldrich syndrome (D82.0)

D69.41 Evans syndrome

D69.42 Congenital and hereditary thrombocytopenia purpura

Congenital thrombocytopenia

Hereditary thrombocytopenia

Code first: congential or hereditary disorder, such as:

thrombocytopenia with absent radius (TAR syndrome) (Q87.2)

D69.49 Other primary thrombocytopenia

Megakaryocytic hypoplasia

Primary thrombocytopenia NOS

D69.5 Secondary thrombocytopenia

Excludes1: heparin induced thrombocytopenia (HIT) (D75.82)

transient thrombocytopenia of newborn (P61.0)

D69.6 Thrombocytopenia, unspecified

D69.8 Other specified hemorrhagic conditions

Capillary fragility (hereditary)

Vascular pseudohemophilia

D69.9 Hemorrhagic condition, unspecified

Other disorders of blood and blood-forming organs (D70-D77)

D70 Neutropenia

Includes: agranulocytosis

decreased absolute neurophile count (ANC)

Use additional code for any associated:

fever (R50.81)

mucositis (J34.81, K12.3-, K12.4, K92.81, N76.81)

Excludes1: neutropenic splenomegaly (D73.81)

transient neonatal neutropenia (P61.5)

D70.0 Congenital agranulocytosis

Congenital neutropenia

Infantile genetic agranulocytosis

Kostmann's disease

D70.1 Agranulocytosis secondary to cancer chemotherapy

Code first (T45.1-) to identify drug

Code also underlying neoplasm

D70.2 Other drug-induced agranulocytosis

Code first (T36-T50) to identify drug

D70.3 Neutropenia due to infection

D70.4 Cyclic neutropenia

Cyclic hematopoiesis

Periodic neutropenia

D70.8 Other neutropenia

D70.9 Neutropenia, unspecified

D71 Functional disorders of polymorphonuclear neutrophils

Includes: cell membrane receptor complex [CR3] defect

chronic (childhood) granulomatous disease

congenital dysphagocytosis

progressive septic granulomatosis

D72 Other disorders of white blood cells

Excludes1: basophilia (D72.824)

immunity disorders (D80-D89)

neutropenia (D70)

preleukemia (syndrome) (D46.9)

D72.0 Genetic anomalies of leukocytes

Alder (granulation) (granulocyte) anomaly

Alder syndrome

Hereditary leukocytic hypersegmentation

Hereditary leukocytic hyposegmentation

Hereditary leukomelanopathy

May-Hegglin (granulation) (granulocyte) anomaly

May-Hegglin syndrome

PelgerHu?t (granulation) (granulocyte) anomaly

Pelger-Hu?t syndrome

Excludes1: Chediak (-Steinbrinck)-Higashi syndrome (E70.330)

D72.1 Eosinophilia

Allergic eosinophilia

Hereditary eosinophilia

Excludes1: Löffler's syndrome (J82)

pulmonary eosinophilia (J82)

D72.8 Other specified disorders of white blood cells

Excludes1: leukemia (C91-C95)

D72.81 Decreased white blood cell count

Excludes1: neutropenia (D70.-)

D72.810 Lymphocytopenia

Decreased lymphocytes

D72.818 Other decreased white blood cell count

Basophilic leukopenia

Eosinophilic leukopenia

Monocytopenia

Other decreased leukocytes

Plasmacytopenia

D72.819 Decreased white blood cell count, unspecified

Decreased leukocytes, unspecified

Leukocytopenia, unspecified

Leukopenia

Excludes1: malignant leukopenia (D70.9)

D72.82 Elevated white blood cell count

Excludes1: eosinophilia (D72.1)

D72.820 Lymphocytosis (symptomatic)

Elevated lymphocytes

D72.821 Monocytosis (symptomatic)

Excludes1: infectious mononucleosis (B27.-)

D72.822 Plasmacytosis

D72.823 Leukemoid reaction

Basophilic leukemoid reaction

Leukemoid reaction NOS

Lymphocytic leukemoid reaction

Monocytic leukemoid reaction

Myelocytic leukemoid reaction

Neutrophilic leukemoid reaction

D72.824 Basophilia

D72.825 Bandemia

Bandemia without diagnosis of specific infection

Excludes1: confirmed infection - code to infection

leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)

D72.828 Other elevated white blood cell count

D72.829 Elevated white blood cell count, unspecified

Elevated leukocytes, unspecified

Leukocytosis, unspecified

D72.89 Other specified disorders of white blood cells

Abnormality of white blood cells NEC

D72.9 Disorder of white blood cells, unspecified

Abnormal leukocyte differential NOS

D73 Diseases of spleen

D73.0 Hyposplenism

Atrophy of spleen

Excludes1: asplenia (congenital) (Q89.01)

postsurgical absence of spleen (Z90.81)

D73.1 Hypersplenism

Excludes1: neutropenic splenomegaly (D73.81)

primary splenic neutropenia (D73.81)

splenitis, splenomegaly in late syphilis (A52.79)

splenitis, splenomegaly in tuberculosis (A18.85)

splenomegaly NOS (R16.1)

splenomegaly congenital (Q89.0)

D73.2 Chronic congestive splenomegaly

D73.3 Abscess of spleen

D73.4 Cyst of spleen

D73.5 Infarction of spleen

Splenic rupture, nontraumatic

Torsion of spleen

Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)

traumatic rupture of spleen (S36.03-)

D73.8 Other diseases of spleen

D73.81 Neutropenic splenomegaly

Werner-Schultz disease

D73.89 Other diseases of spleen

Fibrosis of spleen NOS

Perisplenitis

Splenitis NOS

D73.9 Disease of spleen, unspecified

D74 Methemoglobinemia

D74.0 Congenital methemoglobinemia

Congenital NADH-methemoglobin reductase deficiency

Hemoglobin-M [Hb-M] disease

Methemoglobinemia, hereditary

D74.8 Other methemoglobinemias

Acquired methemoglobinemia (with sulfhemoglobinemia)

Toxic methemoglobinemia

D74.9 Methemoglobinemia, unspecified

D75 Other and unspecified diseases of blood and blood-forming organs

Excludes2: acute lymphadenitis (L04.-)

chronic lymphadenitis (I88.1)

enlarged lymph nodes (R59.-)

hypergammaglobulinemia NOS (D89.2)

lymphadenitis NOS (I88.9)

mesenteric lymphadenitis (acute) (chronic) (I88.0)

D75.0 Familial erythrocytosis

Benign polycythemia

Familial polycythemia

Excludes1: hereditary ovalocytosis (D58.1)

D75.1 Secondary polycythemia

Acquired polycythemia

Emotional polycythemia

Erythrocytosis NOS

Hypoxemic polycythemia

Nephrogenous polycythemia

Polycythemia due to erythropoietin

Polycythemia due to fall in plasma volume

Polycythemia due to high altitude

Polycythemia due to stress

Polycythemia NOS

Relative polycythemia

Excludes1: polycythemia neonatorum (P61.1)

polycythemia vera (D45)

D75.8 Other specified diseases of blood and blood-forming organs

D75.81 Myelofibrosis

Myelofibrosis NOS

Secondary myelofibrosis NOS

Code first the underlying disorder, such as:

malignant neoplasm of breast (C50.-)

Use additional code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)

Use additional external cause code, if due to antineoplastic chemotherapy (T45.1-)

Excludes1: acute myelofibrosis (C94.4-)

idiopathic myelofibrosis (D47.1)

leukoerythroblastic anemia (D61.82)

myelofibrosis with myeloid metaplasia (D47.4)

myelophthisic anemia (D61.82)

myelophthisis (D61.82)

primary myelofibrosis (D47.1)

D75.82 Heparin induced thrombocytopenia (HIT)

D75.89 Other specified diseases of blood and blood-forming organs

D75.9 Disease of blood and blood-forming organs, unspecified

D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

Excludes1: (Abt-) Letterer-Siwe disease (C96.0)

eosinophilic granuloma (C96.6)

Hand-Schüller-Christian disease (C96.5)

histiocytic sarcoma (C96.a)

histiocytosis X, multifocal (C96.5)

histiocytosis X, unifocal (C96.6)

malignant histiocytosis (C96.a)

Langerhans-cell histiocytosis, multifocal (C96.5)

Langerhans-cell histiocytosis NOS (C96.6)

Langerhans-cell histiocytosis, unifocal (C96.6)

leukemic reticuloendotheliosis or reticulosis (C91.4-)

lipomelanotic reticuloendotheliosis or reticulosis (I89.8)

D76.1 Hemophagocytic lymphohistiocytosis

Familial hemophagocytic reticulosis

Histiocytoses of mononuclear phagocytes

D76.2 Hemophagocytic syndrome, infection-associated

Use additional code to identify infectious agent or disease.

D76.3 Other histiocytosis syndromes

Reticulohistiocytoma (giant-cell)

Sinus histiocytosis with massive lymphadenopathy

Xanthogranuloma

D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere

Code first underlying disease, such as:

amyloidosis (E85.-)

congenital early syphilis (A50.0)

echinococcosis (B67.0-B67.9)

malaria (B50.0-B54)

schistosomiasis [bilharziasis] (B65.0-B65.9)

vitamin C deficiency (E54)

Excludes1: rupture of spleen due to Plasmodium vivax malaria (B51.0)

splenitis, splenomegaly in:

late syphilis (A52.79)

tuberculosis (A18.85)

Intraoperative and postprocedural complications of the spleen (D78)

D78 Intraoperative and postprocedural complications of the spleen

D78.0 Intraoperative hemorrhage and hematoma of spleen complicating a procedure

Excludes1: intraoperative hemorrhage and hematoma of spleen due to accidental puncture or laceration during a procedure (D78.1-)

D78.01 Intraoperative hemorrhage and hematoma of spleen complicating a procedure on the spleen

D78.02 Intraoperative hemorrhage and hematoma of spleen complicating other procedure

D78.1 Accidental puncture and laceration of spleen during a procedure

D78.11 Accidental puncture and laceration of spleen during a procedure on the spleen

D78.12 Accidental puncture and laceration of spleen during other procedure

D78.2 Postprocedural hemorrhage and hematoma of spleen following a procedure

D78.21 Postprocedural hemorrhage and hematoma of spleen following a procedure on the spleen

D78.22 Postprocedural hemorrhage and hematoma of spleen following other procedure

D78.8 Other intraoperative and postprocedural complications of spleen

Use additional code, if applicable, to further specify disorder

D78.81 Other intraoperative complications of spleen

D78.89 Other postprocedural complications of spleen

Certain disorders involving the immune mechanism (D80-D89)

Includes: defects in the complement system

immunodeficiency disorders, except human immunodeficiency virus [HIV] disease

sarcoidosis

Excludes1: autoimmune disease (systemic) NOS (M35.9)

functional disorders of polymorphonuclear neutrophils (D71)

human immunodeficiency virus [HIV] disease (B20)

D80 Immunodeficiency with predominantly antibody defects

D80.0 Hereditary hypogammaglobulinemia

Autosomal recessive agammaglobulinemia (Swiss type)

X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)

D80.1 Nonfamilial hypogammaglobulinemia

Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes

Common variable agammaglobulinemia [CVAgamma]

Hypogammaglobulinemia NOS

D80.2 Selective deficiency of immunoglobulin A [IgA]

D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses

D80.4 Selective deficiency of immunoglobulin M [IgM]

D80.5 Immunodeficiency with increased immunoglobulin M [IgM]

D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

D80.7 Transient hypogammaglobulinemia of infancy

D80.8 Other immunodeficiencies with predominantly antibody defects

Kappa light chain deficiency

D80.9 Immunodeficiency with predominantly antibody defects, unspecified

D81 Combined immunodeficiencies

Excludes1: autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis

D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

D81.3 Adenosine deaminase [ADA] deficiency

D81.4 Nezelof's syndrome

D81.5 Purine nucleoside phosphorylase [PNP] deficiency

D81.6 Major histocompatibility complex class I deficiency

Bare lymphocyte syndrome

D81.7 Major histocompatibility complex class II deficiency

D81.8 Other combined immunodeficiencies

D81.81 Biotin-dependent carboxylase deficiency

Multiple carboxylase deficiency

Excludes1: biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

D81.810 Biotinidase deficiency

D81.818 Other biotin-dependent carboxylase deficiency

Holocarboxylase synthetase deficiency

Other multiple carboxylase deficiency

D81.819 Biotin-dependent carboxylase deficiency, unspecified

Multiple carboxylase deficiency, unspecified

D81. 89 Other combined immunodeficiencies

D81.9 Combined immunodeficiency, unspecified

Severe combined immunodeficiency disorder [SCID] NOS

D82 Immunodeficiency associated with other major defects

Excludes1: ataxia telangiectasia [Louis-Bar] (G11.3)

D82.0 Wiskott-Aldrich syndrome

Immunodeficiency with thrombocytopenia and eczema

D82.1 Di George's syndrome

Pharyngeal pouch syndrome

Thymic alymphoplasia

Thymic aplasia or hypoplasia with immunodeficiency

D82.2 Immunodeficiency with short-limbed stature

D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus

X-linked lymphoproliferative disease

D82.4 Hyperimmunoglobulin E [IgE] syndrome

D82.8 Immunodeficiency associated with other specified major defects

D82.9 Immunodeficiency associated with major defect, unspecified

D83 Common variable immunodeficiency

D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders

D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells

D83.8 Other common variable immunodeficiencies

D83.9 Common variable immunodeficiency, unspecified

D84 Other immunodeficiencies

D84.0 Lymphocyte function antigen-1 [LFA-1] defect

D84.1 Defects in the complement system

C1 esterase inhibitor [C1-INH] deficiency

D84.8 Other specified immunodeficiencies

D84.9 Immunodeficiency, unspecified

D86 Sarcoidosis

D86.0 Sarcoidosis of lung

D86.1 Sarcoidosis of lymph nodes

D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes

D86.3 Sarcoidosis of skin

D86.8 Sarcoidosis of other sites

D86.81 Sarcoid meningitis

D86.82 Multiple cranial nerve palsies in sarcoidosis

D86.83 Sarcoid iridocyclitis

D86. 84 Sarcoid pyelonephritis

Tubulo-interstitial nephropathy in sarcoidosis

D86.85 Sarcoid myocarditis

D86.86 Sarcoid arthropathy

Polyarthritis in sarcoidosis

D86.87 Sarcoid myositis

D86.89 Sarcoidosis of other sites

Hepatic granuloma

Uveoparotid fever [Heerfordt]

D86.9 Sarcoidosis, unspecified

D89 Other disorders involving the immune mechanism, not elsewhere classified

Excludes1: hyperglobulinemia NOS (R77.1)

monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2: transplant failure and rejection (T86.-)

D89.0 Polyclonal hypergammaglobulinemia

Benign hypergammaglobulinemic purpura

Polyclonal gammopathy NOS

D89.1 Cryoglobulinemia

Cryoglobulinemic purpura

Cryoglobulinemic vasculitis

Essential cryoglobulinemia

Idiopathic cryoglobulinemia

Mixed cryoglobulinemia

Primary cryoglobulinemia

Secondary cryoglobulinemia

D89.2 Hypergammaglobulinemia, unspecified

D89.3 Immune reconstitution syndrome

Code first (T36-T50) to identify drug, if drug induced

D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified

D89.81 Graft-versus-host disease

Code first underlying cause, such as:

complications of transplanted organs and tissue (T86.-)

complications of blood transfusion (T80.89)

Use additional code to identify associated manifestations, such as:

desquamative dermatitis (L30.8)

diarrhea (R19.7)

elevated bilirubin (R17)

hair loss (L65.9)

D89.810 Acute graft-versus-host disease

D89.811 Chronic graft-versus-host disease

D89.812 Acute on chronic graft-versus-host disease

D89. 813 Graft-versus-host disease, unspecified

D89.82 Autoimmune lymphoproliferative syndrome [ALPS]

D89.89 Other specified disorders involving the immune mechanism, not elsewhere classified

Excludes1: human immunodeficiency virus disease (B20)

D89.9 Disorder involving the immune mechanism, unspecified

Immune diseaseNOS