The war opened badly. On his way to join Gonzaga Giambattista suffered a slight reverse. Bolognese territory was attacked by the Farnesi, and the safety of Bologna itself was doubtful. The Pope was anxious to protect Bologna and called off the chief part of his troops for its defence. Reinforcements reached Parma from Mirandola. Although Mirandola was under French protection it became necessary to attack it, and the double enterprise against Parma and Mirandola proved too much for the scanty forces. The country was ruined but nothing was effected. War had not yet opened between the French King and the Emperor, but the peace concluded with England by Henry II (March 24, 1550), by which Boulogne was restored for a money payment, left him free on that side; and he could choose his own moment for overt hostilities.
Meanwhile the truce between Charles and the Sultan had been broken. A new corsair, Dragut, had established himself on the Tunisian coast of Africa at Mehedia, known as the Port of Africa. His ravages on the neighbouring littoral of Sicily and further afield had rendered action imperative; and in September, 1550, the united fleet of Charles' dominions had attacked and captured his headquarters, though his fleet escaped on this occasion, and again from Dorians blockade in the following spring. Charles could represent that this act of reprisal had been abundantly provoked, but the Sultan had made Dragut his commissioner to rule over the whole of Barbary, and regarded the attack upon him as an attack upon himself. On his return from an expedition against the Sophy of Persia, which the truce with Charles had permitted, the Sultan prepared for war. In July, 1551, a great Turkish fleet appeared in Sicilian waters, and after vainly demanding the restoration of Mehedia, the Ottomans turned upon the Knights of St John, and captured Tripoli (August 14). In September of the same year the Turkish war began afresh in Hungary. Once more Charles had to withstand the simultaneous hostility of the Most Christian King and of the infidels. In the course of 1551 Henry was submitting plans for common action to the Porte, and the use of the Turkish fleet was recommended; war in Hungary being calculated to unite the Germans in defence. The King of France was also in relations with Magdeburg and with Maurice of Saxony.
Under these auspices the Council met once more at Trent in May, 1551, though it was autumn before formal proceedings could be begun. Its prospects were not rosy, for in September, 1551, war opened on the side of Savoy. Although François de Brissac, the French commander, did not push his attack, the necessity of action in two distant fields completely disorganised the imperial finances in Italy. The blockades of Parma and Mirandola were in consequence slackly pursued; the Pope saw little prospect of gain from the war; his debts were burdensome; French hostility threatened him with the failure of French funds; he began to think whether an arrangement with France was not possible.
