| 4.2.4.2 | NIOSH docket submissions | 75 | |||
| RIPT studies | 75 | ||||
| Tests under simulated conditions of use | 98 | ||||
| 4.2.4.3 | Summary | 99 | |||
| 4.3 | Animal Studies | 99 | |||
| 4.3.1 | Published studies | 99 | |||
| Hasegawa et al. 1982a | 99 | ||||
| Hasegawa et al. 1982b | 99 | ||||
| Lofroth 1982 | 99 | ||||
| Certin and Zissu 1983 | 100 | ||||
| Cameron et al. 1986 | 101 | ||||
| Wolkoffet al. 1988 | 101 | ||||
| Anderson 1992 | 101 | ||||
| 4.3.2 | NIOSH docket submissions | 102 | |||
| 4.3.3 | Summary | 105 | |||
| 5 | Summary and Conclusions | 107 | |||
| 5.1 | Irritation of the skin, eyes, and upper respiratory tract | 107 | |||
| 5.1.1 | Strength of the association | 110 | |||
| 5.1.2 | Consistency | 110 | |||
| 5.1.3 | Specificity | 110 | |||
| 5.1.4 | Relationship in time (temporality) | 111 | |||
| 5.1.5 | Biological gradient | 111 | |||
| 5.1.6 | Biological plausibility | 111 | |||
| 5.1.7 | Coherence | 112 | |||
| 5.1.8 | Experimental evidence | 112 | |||
| 5.1.9 | Reasoning by analogy | 113 | |||
| 5.1.10 | Summary | 113 | |||
| 5.2 | Allergic contact dermatitis | 113 | |||
| 5.3 | Systemic reactions | 114 | |||
| 5.4 | Conclusions | 114 | |||
| 6 | Recommendations | 117 | |||
| 6.1 | Historical recommendations in the scientific literature | 117 | |||
| 6.2 | NIOSH recommendations | 118 | |||
| References | 120 | ||||
| Other publications examined | 129 | ||||
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