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test this relation) to that Noble Benefactor to Experimental Philosophy, Mr. Robert Boyle, Dr. Wilkins, and other deserving Persons, That he thought, he could easily contrive a Way to conveigh any liquid thing immediately into the Mass of Blood; videl: By making Ligatures on the Veines, and then opening them on the side of the Ligature towards the Heart, and by putting into them slender Syringes or Quills, fastened to Bladders (in the manner of Clyster-pipes) containing the matter to be injected; performing that Operation upon pretty big and lean doggs, that the Vessels might be large enough and easily accessible.
This Proposition being made, M. Boyle soon gave order for an Apparatus, to put it to Experiment; wherein at several times, upon several Doggs, Opium & the Infusion of Crocus Metallorum were injected into that part of the hind-legs of those Animals, whence the larger Vessels, that carry the Blood, are most easy to be taken hold of: whereof the success was, that the Opium, being soon circulated into the Brain, did within a Short time stupify, though not kill the Dog; but a large Dose of the Crocus Metallorum, made an other Dog vomit up Life and all: All which is more amply and circumstantially delivered by Mr. Boyle in his Excellent Book of the Usefulness of Experimental Philosophy, Part 2. Essay 2. pag. 53. 54. 55. Where 'tis also mention'd, that the fame of this Invention and of the succeeding Tryals being spread, and particularly coming to the knowledge of a foreign Ambasssadour, that was Curious, and then resided in London, it was by him tryed with some Crocus Metallorum, upon a Malefactor, that was an inferiour Servant of his, with this success, that the Fellow, as soon as ever the Injection began to be made, did, either really or craftily, fall into a swoon; whereby, being unwilling to prosecute so hazardous an Experiment, they desisted, without seeing any other effect of it, save that it was told the Ambassadour, that it wrought once downwards with him. Since which time, it hath been frequently practised both in Oxford & London; as well before the Royal Society, as elsewhere. And particularly that Learned
