verted layer, or hypoblast, are developed the alimentary canal along with those parts of its appended organs, liver, pancreas, &c., which are concerned in delivering their secretions into the alimentary canal, as well as the linings of those ramifying tubes in the lungs which convey air to the places where gaseous exchange is effected. And from the mesoblast originate the bones, the muscles, the heart and blood-vessels, and the lymphatics, together with such parts of various internal organs as are most remotely concerned with the outer world. Minor qualifications being admitted, there remain the broad general facts, that out of that part of the external layer which remains permanently external, are developed all the structures which carry on intercourse with the medium and its contents, active and passive; out of the introverted part of this external layer, are developed the structures which carry on intercourse with the quasi-external substances that are taken into the interior—solid food, water, and air; while out of the mesoblast are developed structures which have never had, from first to last, any intercourse with the environment. Let us contemplate these general facts.
Who would have imagined that the nervous system is a modified portion of the primitive epidermis? In the absence of proofs furnished by the concurrent testimony of embryologists during the last thirty or forty years, who would have believed that the brain arises from an infolded tract of the outer skin, which, sinking down beneath the surface, becomes imbedded in other tissues and eventually surrounded by a bony case? Yet the human nervous system in common with the nervous systems of lower animals is thus originated. In the words of Mr. Balfour, early embryological changes imply that—
Less startling perhaps, though still startling enough, is the fact that the eye is evolved out of a portion of the skin; and that while the crystalline lens and its surroundings thus originate, the "percipient portions of the organs of special sense, especially of optic organs, are often formed from the same part of the primitive epidermis" which forms the central nervous system.[2] Similarly is it with the organs for smelling and hearing. These, too, begin as sacs formed by infoldings of the epidermis; and while their parts are developing they are joined from within by nervous structures which were themselves epidermic in origin. How are we to interpret these strange transformations? Observing, as we pass, how absurd from the point of view of
