ism, nor the mere sorting of materials already present in the germ cells, though this does take place, but rather it consists in the formation of new materials and qualities—of new structures and functions—by the combination and interaction of the germinal elements present in the oosperm. In similar manner the combination and interaction of chemical elements yield new substances and qualities which are not to be observed in the elements themselves. Such new substances and qualities, whether in the organic or in the inorganic world, do not arise by the gradual unfolding of what was present from the beginning, but they are produced by a process of "creative synthesis."
Modern studies of germ cells have shown that they are much more complex than was formerly believed to be the case; they may even contain different "organ-forming substances" which in the course of development give rise to particular organs; these substances may be so placed in the egg as to foreshadow the polarity, symmetry and pattern of the embryo, but even the most highly organized egg is relatively simple as compared with the animal into which it ultimately develops. Increasing complexity, which is the essence of development, is caused by the combination and interaction of germinal substances under the influence of the environment. The organization of the oosperm may be compared to the arrangement of tubes and flasks in a complicated chemical operation; they stand in a definite relation to one another and each contains specific substances. The final result of the operation depends not merely upon the substances used, nor merely upon the way in which the apparatus is set up, but upon both of these things, as well as upon the environmental conditions represented by temperature, pressure, moisture or other extrinsic factors.
Heredity and Environment.—Unquestionably the factors, or causes, of development are to be found not merely in the germ but, also in the environment, not only in intrinsic but also in extrinsic forces; but it is equally certain that the directing and guiding factors of development are in the main intrinsic, and are present in the organization of the germ cells, while the environmental factors exercise chiefly a stimulating, inhibiting or modifying influence on development. In the same dish and under similar environmental conditions, one egg will develop into a worm, another into a sea urchin, another into a fish, and it is certain that the different fate of each egg is determined by conditions intrinsic in the egg itself, rather than by environmental conditions. We should look upon the germ as a living thing, and upon development as one of its functions. Just as the character of any function is determined by the organism, though it may be modified by environment, so the character of development is determined by heredity, i.e., by the organization of the germ cells, though the course and results of development may be modified by environmental conditions.
