Vlll TABLE OF CONTENTS. PAGE Preface - - v CHAPTER I. ON THE PRINCIPLES OF PROTECTIVE INOCULATION AND ON THE PHYSIOLOGY OF IMMUNISATION. i. Machinery of Immunisation a definite Physiological Entity i 2 Machinery of Immunisation a Chemical Machinery 2 3. Chemical Relation between the Substances inoculated and the Products of Immunity which are elaborated in the Organism in response to the Inoculation - 2 4. Specificity of the Antitropic Elements which are produced in the case of each particular Inoculation 4 5. Character of the Antitropic Elements obtained in the case where the Vaccine which is employed contains in addition to substances held in solution also formed Elements - 5 6. Disorganisation and Destruction of Red Blood Corpuscles by Erythrocytotropic Substances and of Bacteria by Bacteriotropic Substances ; and Selection of a Vaccine which will induce the Elaboration of the Antitropic Substances required for the Destruction of these formed Elements - 6 7. Physiology of the Reaction of Immunisation in relation to the proper Adjustment and proper Interspacing of the Doses of Vaccine - 8 8. Law of the Ebb, Flow, and Reflow, and subsequent maintained High Tide of Immunity - . 8 9. Dependence of the Negative Phase upon the Dose of the Vaccine - 11 10. Cumulative Effects of two or more Inoculations - - 12 CHAPTER II. ON THE APPLICATION OF THE PRINCIPLES DEVELOPED ABOVE TO THE PROBLEM OF THE PRODUCTION OF IMMUNITY TO TYPHOID FEVER. 1. General Survey of the Problem 15 2. Nature of the Services which we desire the Typhoid Antitropins to undertake in the Organism 16 3. Question as to what form of Culture, or what Bacterial Derivative, will induce the Organism to furnish the Typhotropic Substances which are required for the Prevention and Mitigation of Typhoid Fever - - 17
