and subsequently confessed had belonged to a person who had died of the plague in Alexandria. The two Moorish officials who opened the boxes were attacked with the plague that night and died in a few hours. The disease spread rapidly throughout Morocco, carrying off eighty per cent of those who were attacked."
I mention these facts in order to emphasize the desirability of disinfecting all articles liable to carry the infection coming from infected places.
Professor Haffkine's preventive inoculation against the plague is still being largely employed in India. This consists in injecting hypodermically sterilized cultures of the bacillus. No curative action is claimed for this treatment, but it is believed to be protective against the disease. It is stated that more than eighty thousand people in India have undergone this form of vaccination, and that the death rate among these has been exceedingly low. However, it is well to be careful in accepting statistical statements on a matter of this nature. In the first place, it is probable that only the more intelligent will submit to vaccination, and these will also employ other means of protecting themselves against the disease. In the second place, there are many thousands of people exposed to the infection, or at least live in infected districts, who have never been vaccinated and who do not acquire the disease.
Three kinds of serum have been used as curative agents in the plague. In 1896 M. Yersin began the use of a specially prepared serum in China. The first cases treated with this preparation did unusually well, and it was hoped that most valuable results would follow from its more extended use. This serum is prepared after the manner of the antitoxine used in the treatment of diphtheria. That used most largely in India is made at the Imperial Institute of Experimental Medicine in St. Petersburg. Numerous physicians in India have reported upon the action of this serum, and none of them favorably. Very recently Dr. Clemow treated fifty cases with this serum, and compared them with fifty other cases treated without the serum. Every other case was selected for the serum treatment. The mortality was exactly the same in each group, forty patients out of fifty dying.
The second serum is that prepared by M. Roux, of the Pasteur Institute in Paris. This is practically the same as the preparation made by M. Yersin, and the results obtained are equally unsatisfactory. In 1897 the writer had the privilege of observing, both at Paris and at St. Petersburg, the preparation of these agents, from which at that time great results were expected. A third preparation is made by Professor Lustig, of Florence. I have been unable, so far, to find any detailed account of the method followed by Pro-
