fessor Lustig in preparing his serum. From all that I can learn, however, it is not a serum, but a sterilized bacterial culture; at any rate, Lustig's preparation has proved probably least valuable of all.
At present (July, 1899) the plague prevails throughout India, and has appeared at various places in Baluchistan and Afghanistan, at Samarkand in the Transcaspian Province of Russia; in Persia, at Bassorah and other points along the Persian Gulf; at several places along the western shore of the Red Sea; at Suez and Alexandria; at Tamatave, in Madagascar; at Port Lewis, Mauritius; at Penang, in the Straits Settlements; at Amoy and Hong Kong, China; and at numerous places in Formosa. For reasons already given, it will not be at all surprising should the recent report that the plague had appeared in Constantinople prove to be true. If it once reaches that place, it is more than likely that it will become scattered throughout the Balkan Peninsula. The sad death of Professor Müller and his laboratory servant, at Vienna, from the plague bacillus which Professor Müller brought from Bombay, shows the necessity for caution in handling the germ of this disease.
Are we in America in danger of the plague? I will have to answer this question very much as I did two years ago: "Yes, we are in danger; but this danger, being foreseen, may be easily avoided." In my opinion, our most vulnerable point is along the Pacific coast. With the plague at Hong Kong, it is possible that it may be transferred to Manila, and the transports bringing soldiers to this country may also bring the infection. However, I think the chances of this happening are small. The length of time required to make the voyage from Manila to San Francisco is so great that, with the infection on board, it would be almost certain to manifest itself before reaching our shores, and, knowing its presence on board a ship reaching San Francisco or any other point on the western coast, thorough inspection and disinfection will keep the disease out of this country. The probabilities are that for several years to come the larger cities of India, at least, will remain infected, and our sanitary authorities must be vigilant. The fact that, if the plague reaches us at all, it must come by sea, that a long voyage must be made before it can reach us, and that the disease will most probably appear on board ship before arrival at any American port—all these conditions are in our favor. The General Government should take upon itself the control of all measures to prevent the introduction of infectious diseases from without. Quarantine detention is a relic of ignorance of the true nature of infectious diseases. All transports and other vessels between Manila and this country should be provided with proper disinfecting apparatus. The Government should supply the Ma-
